Degenerative Diseases

Here's your chance to contrast the pathophysiology of degenerative diseases!

Match the items on the left to the items on the right.

Disorder of the basal ganglia involving the dopaminergic nigrostriatal pathway which produces a characteristic tremor, rigidity, and bradykinesia.
Inherited as an autosomal dominant trait resulting in a severe degeneration of the basal ganglia particularly the caudate and putamen nuclei, and the frontal cerebral cortex. Progressive intellectual dysfunction and abnormal movement are common.
A dysimmune disorder involving the degeneration of the CNS myelin resulting in plaque formation and progressive brain dysfunction resulting frequently in vision disorders, muscle weakness, numbness, ataxia, hypotonia - all dependent upon where in the brain the inflammation and plaque formation occurs.
Potentially a genetic disorder, this disorder results in the progressive lower and upper motor neuron degeneration resulting in progressive weakness, paresis, and muscle atrophy.
A humoral & cell-mediated immunologic reaction of the peripheral nerve myelin that produces demyelination and inflammation of the axons. Progressive ascending paresis/paralysis of occurs. If the nerve cell body survives, regeneration and restoration of motor activity occurs.
A chronic autoimmune disease of the neuromuscular junction where antibodies are produced to block acetylcholine receptor sites resulting in severe muscle fatigue and can lead to quadriparesis or quadriplegia.

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